When a couple is having difficulty conceiving, a doctor may suggest IVF. But sometimes there are not enough standard protocols. The spouses undergo the procedure, but the embryos stop developing or pregnancy does not occur. In such a situation, reproductologists and embryologists are looking for ways to more accurately select germ cells for fertilization. One of these methods is the PIXIE procedure. Full information about the service and other ART methods can be found on the website.
Let's figure it out simply and without complicated terms: what is the essence of this method and how it differs from the standard ICSI.
How does a PIXIE differ from a regular ICSI
To understand PIXIE, it's worth remembering how the ICSI method works.
In classical ICSI, the embryologist selects the sperm under a microscope. The specialist evaluates the cell externally: looks at the shape, structure and how it moves. Then the selected sperm is injected directly into the egg with a microneedle.
This approach solves many problems, but it has a natural limitation. Externally, a smooth and mobile sperm is not always perfect from the inside. His DNA may be damaged or his internal structures may not be fully formed. A microscope won't show it.
PIXIE is an advanced version of ICSI. Here, a biochemical check is added to the visual selection. It helps to assess the physiological maturity of the cell.
The essence of the method: how the "natural filter" works
In nature, the fertilization process is thought out to the smallest detail. The protective shell of the egg contains hyaluronic acid. During natural conception, only the sperm that has matured special receptors can contact the egg.
A mature cell easily attaches to hyaluronic acid. An immature person can't do this, even if she looks great and swims fast.
The PIXIE method recreates such natural selection in a laboratory dish.:
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The spermatozoa are placed in a medium with a hyaluronic acid gel.
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Mature cells with complete DNA recognize the substance and bind to it, briefly sticking to the surface.
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Immature or defective cells are left to float freely.
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The embryologist takes exactly the bound, mature sperm and fertilizes the egg with it.
This check reduces the element of randomness when choosing a cell.
How does the procedure work and do I need special training?
For the patients themselves, the PIXIE process practically does not differ from the standard IVF or ICSI program. All the key work takes place in the embryology laboratory.
The man gives the biomaterial on the day of the puncture